Willson Contreras hit a go-ahead home run in a four-run sixth inning and the St. Louis Cardinals beat the Pittsburgh Pirates 6-3 on Monday night for their third straight victory.

St. Louis Cardinals Willson Contreras celebrates after hitting a two-run home run on Monday, May 5, 2025, in the sixth inning of a game against the Pittsburgh Pirates at Busch

The Pittsburgh Pirates will face off against the St. Louis Cardinals on the road for a three game series at Busch Stadium. Joey Bart returns to catcher and will hit fourth in the lineup, coming in for Henry Davis who was the catcher in the 4-0 shutout defeat vs.

Preview the May 6 matchup between the Pittsburgh Pirates and St. Louis Cardinals with odds over/under, game spread, betting lines and more.

It is Monday, May 5, and the Pirates (12-23) are in St. Louis to take on the Cardinals (16-19). Carmen Mlodzinski is slated to take the mound for Pittsburgh against Miles Mikolas for St. Louis. Pittsburgh has lost four straight games and seven of the past eight,

Xander Bogaerts had two hits and three RBI to lead the San Diego Padres to a 4-0 victory over the host Pittsburgh Pirates on Sunday afternoon.

Preview the May 4 matchup between the Pittsburgh Pirates and San Diego Padres with odds over/under, game spread, betting lines and more.

Pregame analysis and predictions of the San Diego Padres vs. Pittsburgh Pirates MLB game to be played on May 4, 2025 on ESPN.