Cornell researchers have found a new and potentially more accurate way to see what proteins are doing inside living ...

The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component of this system are pattern recognition receptors, which recognize non-self ...

The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component ...

In a study of human immune cells infected with HIV, the virus that causes AIDS, scientists at Johns Hopkins Medicine say a ...

Scientists have discovered the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact ...

Scientists have made a discovery that has the potential to pave the way to more efficient vaccine and mRNA drug delivery.

Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big ...

Details appeared recently in Nature Biomedical Engineering, in an article titled, “Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical ...

Siloxane nanoparticles unlock precise organ targeting for mRNA therapy Changes to chemical structure allow for tissue-specific delivery Date: October 1, 2024 ...

By adjusting the chemical structure of lipid nanoparticles, the researchers were able to target different organs, presaging a new era in precision medicine. Credit: Lulu Xue and Michael J. Mitchell ...

They tested mRNA structures with zero to three branches and three different kinds of chemical modifications. The modifications were phosphorothioate (PS), DNA, and 2’-O-methoxyethyl (2MOE).

We’re also looking at ways to temporarily change the mRNA chemical structure to keep it from degrading in the vial, then have it revert to its native form in the body.” In substances that rely on mRNA ...