Notre Dame and Penn State are set for the College Football Playoff Orange Bowl semifinal with a shot at the national title matchup on the line. Here’s the latest prediction for the game from an expert analytical model that projects scores and picks winners.

Jimmie Kaylor revealed his College Football Playoff semifinal picks for Penn State vs. Notre Dame in the 2025 Orange Bowl on Thursday

Jan 2, 2025; New Orleans, LA, USA; Notre Dame Fighting Irish head coach Marcus Freeman (R) reacts on the sidelines in the final minute against the Georgia Bulldogs during the fourth quarter at Caesars Superdome. Mandatory Credit: Geoff Burke-Imagn Images