ACROBiosystems has developed a series of specialized proteases for the screening and validation of ADC linkers, focusing on ...

Washington State University researchers have discovered how the bacteria that cause anaplasmosis and Lyme disease hijack ...

SARS-CoV and SARS-CoV-2 bind to the human ACE2 receptor in practically identical conformations, although several residues of the receptor-binding domain (RBD) differ between them. Herein, we have used ...

Figure 1.Heparin mediates SARS-CoV-2 Omicron BA.1 interaction with α v β 3 integrin. (A) BA.1 (blue line) and XBB.1.5 (purple line) RBDs or BA.1 (red line) and XBB.1.5 (black line) spike proteins were ...

Among the defining achievements of SG60 is Singapore’s transformation into a global health innovator. The latest chapter ...

Scientists have unearthed a rare class of ultra-potent antibodies derived from llamas that can neutralize a vast array of coronaviruses—including SARS-CoV-1 and multiple forms of SARS-CoV-2, both old ...

Powerful llama-derived antibodies could be the key to stopping not just current SARS viruses, but future ones too. Scientists ...

The team used a similar approach to model the dynamic transformations that the SARS-CoV-2 Spike protein undergoes after binding its receptor and while literally moving towards fusion. To accomplish ...

Multidisciplinary AI- and physics-driven modeling of the viral fusion process has enabled the discovery of an orally available drug inhibiting infection with multiple coronaviruses.

Several lines of experimental and computational studies revealed that the intrinsic disorder regions of N protein contain putative binding sites for different host proteins (Jia et al., 2022; Huang et ...

Inspired by Viral Spike Proteins, ... yield binding affinities that are between 10 and 1,000 times stronger than those achieved with monovalent binders. In addition to being stronger, ...