"The results were striking," says Shunsuke Mori, lead author. "We found that approximately 10% of clonally expanded T cell repertoire in lupus patients recognized neoself-antigens. Furthermore ...

"Who are you?" This question, in its many variations, is almost inevitable in school applications, job interviews or introspective moments. We spend years, perhaps our entire lives, unraveling the ...

But with autoimmune diseases, the T cells attack a body's own healthy molecules, called self-antigens, Science explained. The University of Chicago team found that by attaching a sugar protein ...

Infectious agents affect the ability of T cells to detect self antigens by cross-reaction (molecular mimicry). As we discussed above, infectious agents provide their own adjuvants, therefore T ...

Autoimmune responses to tissue-restricted self-antigens both humoral (antibody mediated) and cellular (predominantly of the IL-17 type) are pathogenic for chronic rejection. Alloimmune responses ...

The immune system generates antibodies and antigen-specific T-cells as basic elements of the immune networks that differentiate self from non-self in a finely tuned manner. The antigen-specific ...

Antigen processing and presentation is the mechanism ... Figure 2: Contribution of pathogens and self peptides to loading of MHC class II molecules in dendritic cells. Conversely, autophagy ...