A study published in mBio details the vulnerability of coronaviruses to inhibitors of a small protein domain called Mac1, or the "macrodomain," found in all coronaviruses such as SARS-CoV-2 and ...

Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), understanding the mechanisms underlying ...

Background The COVID-19 pandemic continues to be a worldwide threat and effective antiviral drugs and vaccines are being developed in a joint global effort. However, some elderly and ...

A new SARS-CoV-2 variant, NB.1.8.1, may now account for more than one-third of all COVID-19 cases in the US, health officials say.

Endocytosis has been the bane of the intracellular delivery efficiency of nanoscale systems. A class of delivery systems, viz., cell membrane-coated nanoparticles (CMNPs), show efficacious and even ...

WYS-633 also prevented SARS-CoV-1, MERS, and multiple SARS-CoV-2 variants from infecting cells ... discovery of drugs against a number of other virus families utilizing membrane fusion proteins, ...

Multidisciplinary AI- and physics-driven modeling of the viral fusion process has enabled the discovery of an orally available drug inhibiting infection with multiple coronaviruses.

(A) Neutralization mechanisms: Following the binding of NAbs (via Fab) to the RBD of the S1 subunit of SARS-CoV-2, the virus-antibody complex is formed, which prevents the viral binding to host ...

It is well recognized that SARS-CoV-2 S protein (Spike protein) has a key role in the infection of human cells by mediating the fusion of viral and cellular membranes. The main step of the virus ...

We then assessed the properties of NB.1.8.1 by virological experiments. A lentivirus-based pseudovirus assay showed that the infectivity of NB.1.8.1 was significantly higher (2·5-fold; p<0·0001) than ...