Randomized 87 patients to date in Phase 2b CHASE trial of KPI-012 in Persistent Corneal Epithelial Defect (PCED) ---- Continuing enrollment ...

The following is a summary of “A Novel Molecular Regulatory Network in Bone Marrow Mesenchymal Stem Cells for Age-Related Osteoporosis,” published in the March 2025 issue of Clinical Endocrinology by ...

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

Depleting SUN1 and SUN2 proteins of the inner nuclear envelope halts adipogenic differentiation in mesenchymal stem cells via heterochromatic accrual on lineage genes independent of LINC complex ...

Get Instant Summarized Text (Gist) Blood stem cells evolve differently in humans and mice, offering insights into tissue aging. In humans, blood production in older age relies on a few dominant ...

In this study, we showed that the secretome of mesenchymal stem cells (MSCs), a complex mixture of growth factors, cytokines, extracellular vesicles, and other cell-secreted molecules with therapeutic ...

Regenerative medicine, a rapidly advancing field, can be generally defined as a therapeutic methodology for the repair, regeneration, or replacement of damaged or diseased human cells and tissues.

Recently, investigation into the dynamic secretome of Adipose-derived Mesenchymal Stem Cells (ASCs), have shown promise in augmenting the wound healing response of chronic diabetic wounds. However, ...

Interaction between adult stem cells and their progeny is critical for tissue homeostasis and regeneration. In multiple organs, mesenchymal stem cells (MSCs) give rise to transit amplifying cells ...