Once this occurs, the repaired gene should function normally. Ethics in Real Life: The Case of Jesse Gelsinger To begin thinking about some of the ethical issues in gene therapy research, and human ...

David Mack/Photo Researchers, Inc. Since 1998, when 18-year-old Jesse Gelsinger died in a clinical trial at the University of Pennsylvania, the news on gene therapy hasn't gotten much better. In a ...

In 1999, Jesse Gelsinger died of multiple organ failure four days after receiving adenovirus-based therapy for a rare liver disorder. In 2002, a child developed leukemia after receiving retroviral ...

He became widely known as the lead scientist in a gene therapy trial that led to the 1999 death of 18-year-old Jesse Gelsinger, the first person to die as a result of gene therapy. The tragedy led ...

Jesse Gelsinger suffered from ornithine transcarbamylase (OTC) deficiency, an enzyme deficiency that causes an inability to break down ammonia (Somia & Verma, 2000). Four days after receiving an ...