G Protein-Coupled Receptors (GPCRs) in advancing GPCR-targeted therapies, including the use of agonists, antagonists, biased ...

Women have a higher proportion of key immune cells between puberty and menopause, which may be linked to the sex hormone estrogen and explain why they are less susceptible to certain infectious ...

Scientists at Pennington Biomedical Research Center have gained greater clarity in the brain regions and neurons that control metabolism, body temperature and energy use.

Extracellular signalling molecules are cues, such as growth factors, hormones ... are recognized by cognate receptors on the surface of target cells to initiate intracellular signalling cascades ...

In addition to their being crucial in metabolic energy, ANs are pivotal mediators of both extracellular and intracellular signaling. Both the release of ATP or NAD and their conversion by ectoenzymes ...

Biophysical Chemistry and Diagnostics, Faculty of Chemistry, Bielefeld University, Bielefeld 33615, Germany Biophysical Chemistry and Diagnostics, Medical School OWL, Bielefeld University, Bielefeld ...

In this important study, Li and others identified cell membrane receptors for juvenile hormone (JH), a terpenoid hormone in insects that regulates their development and reproduction. While ...

In the first years following a diagnosis, survival rates are lower, compared to hormone receptor-positive cancers, but, unlike hormonal receptor-positive tumors—which are notorious for having late ...

Recent studies have shown that CD44, a transmembrane protein that plays an essential role in transducing extracellular stimuli into intracellular ... Unlike GLP-1 receptor agonists, which ...

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore (A.B., A.K.-K.) Department of Biochemistry and Molecular ...

Juvenile Hormone (JH) plays a key role in insect development and physiology. Although the intracellular receptor for JH was identified long ago, a number of studies have shown that part of JH ...