Pica, N. et al. Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses. Proc. Natl Acad. Sci. USA 109, 2573–2578 ...

Monoclonal antibodies (mAbs) that bind the stalk domain of the influenza hemagglutinin glycoprotein have been shown to have broadly neutralizing activity against diverse influenza subtypes. In ...

R. Nachbagauer et al. Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets. Journal of Virology. Published online March 2016. doi: 10.1128/JVI.02481-15.

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies. Nature Communications , 2018; 9 (1) DOI: 10.1038/s41467-018-05482-0 Cite This Page : ...

A new vaccine from Duke helps the immune system target the stalk of the hemagglutinin protein, rather than its top. view more . Credit: U.S. Centers for Disease Control.

For decades, researchers have sought out strategies to circumvent the rapid incessant evolution of flu strains. These strategies have varied from focusing on neuraminidase, to using stalk ...

The stalk, by comparison, changes much less. “A number of groups have gone through and experimentally mutagenized the whole hemagglutinin and asked ‘which areas can change and still allow the ...

FI6 targets HA's stalk, ... Wang TT, et al. Influenza virus vaccine based on the conserved hemagglutinin stalk domain. MBio 2010;1:pii:e00018-10. Crossref. PubMed. Web of Science. Google Scholar. 5.

A protein on the surface of influenza viruses, hemagglutinin, shepherds the virus into host cells. Hemagglutinin is comprised of a 'head' (variable) and a 'stalk' (varies less from strain to strain).

Researchers have designed experimental influenza vaccines to be more universal, spurring the body to create antibodies against the less-variable stalk region of HA, which extends like a stem ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. Mathur, Neha. (2022, November 15). Hemagglutinin stem immunogens may hold the key for broad ...

Vaccination with antigenically complex hemagglutinin mixtures confers broad protection from influenza disease. Science Translational Medicine , 2024; 16 (745) DOI: 10.1126/scitranslmed.adj4685 ...