The minus-strand HBV DNA genome is synthesized by reverse transcription of the 3.5-kb pregenomic RNA (pgRNA), after copackaging of the pgRNA and HBV polymerase inside the icosahedral nucleocapsids.

Chronic hepatitis B infection is primarily driven by persistence of HBV cccDNA and integration of HBV DNA into the human genome in liver cells, the primary source of HBsAg in late-stage disease.

Chronic hepatitis B infection is primarily driven by persistence of HBV cccDNA and integration of HBV DNA into the human genome in liver cells, the primary source of hepatitis B surface antigen ...

Early in infection, HBV establishes an independent “minichromosome” consisting of the viral covalently closed circular DNA (cccDNA) genome and host histones.

Hepatitis B e antigen usually indicates active HBV replication and risk of transmission of infection. Seroconversion from HBeAg to anti-HBe is usually associated with serum HBV DNA undetectable by ...

It is a leading cause of liver cancer, responsible for 50%–80% of hepatocellular carcinoma cases globally. 1 Chronic HBV infection leads to the integration of HBV DNA into the host genome ...

Precision BioSciences, Inc. (Nasdaq: DTIL), a clinical stage gene editing company utilizing its novel proprietary ARCUS® platform to develop in vivo gene editing therapies for sophisticated gene ...

- PBGENE-HBV is the first in vivo gene editing program for chronic hepatitis B virus to move into global clinical trials - Company to host investor event highlighting clinical candidate safety ...