Methotrexate is an antimetabolite that ... and competing with folic acid in cancer cells, resulting in folic acid deficiency and cell death. Normal cells are not spared; thus, significant side ...
Here’s why these vitamins and minerals are so important for maintaining your health — and what you can do about a deficiency. “When patients have a flare-up of Crohn’s, they can have ...
Folate deficiency could also rarely cause subacute combined ... However, some genetic (DARS mutation, biotinidase deficiency) or acquired (B 12 deficiency, methotrexate and nitrous oxide toxicity) ...
Homologous recombination deficiency (HRD) was evaluated through structural ... and influencing the tumor’s sensitivity to drugs targeting the folate pathway, such as methotrexate. The MTHFR gene is ...
Objective Neural tube defects (NTDs) are a preventable folate deficiency disorder; increasing folic acid intake through food ...
In September, the Nigerian government made an important change to its food fortification program to date — a set of standards ...
Vitamin B12 Deficiency Symptoms: Vitamin B12 is an essential nutrient that plays a vital role in your overall health. It is crucial for red blood cell production, DNA synthesis, and the proper ...
In fact, doctors estimate as many as one in three adults may have undiagnosed iron deficiency. Iron is a key nutrient that helps red blood cells carry oxygen throughout the body. “So if we’re ...
Relative energy deficiency in sport (REDs) is a condition that develops when an athlete doesn’t get enough fuel to support their body’s energy demands. Relative energy deficiency in sport ...
Nat Clin Pract Rheumatol. 2007;3(1):26-34. Slow transport via folate receptor (lower affinity for methotrexate than for folic acid) Increased drug efflux via ATP-binding cassette (ABC) subfamily ...
The causes are largely unknown, but a new study points to a link involving a chromosomal microdeletion -- and also underscores the value of folic acid as a preventive ... Adding Folic Acid to ...