Physiological extracellular matrix (ECM) calcification or mineralization is restricted to bones, teeth and the hypertrophic zone of growth plate cartilage. In contrast, pathological ECM ...

Right now, people only think about the matrix,” Plikus said. “But in lipo-cartilage, biomechanics derive from the organelles inside of the cells, not from the extracellular matrix. And that is ...

Rhobo6, a light microscopy probe, gives scientists an unprecedented look at the extracellular matrix -- the collection of organized molecular structures that fills the spaces between cells in our ...

Recent research has uncovered a pivotal role for hyaluronic acid (aka hyaluronan, HA), a glycosaminoglycan found in the ...

In severe cases, cartilage wears so thin that joints ... Once inside the body, these nanofibers mimic the extracellular matrix of surrounding tissue, matching its structure, motion, and bioactive ...

One recent study in mice uncovered that menopause led to a drop in 17beta-estradiol and progesterone, which increased cartilage aging, degeneration, and disassembly of the extracellular matrix.

Cartilage’s biomechanical properties – it is strong but flexible – are due to cells called chondrocytes secreting large amounts of collagen-rich extracellular matrix (ECM), which surrounds ...

Cartilage comprises two major components, the extracellular matrix (the surrounding proteins that provide structure) and chondrocytes, the resident cell population. In OA, the health of both these ...