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It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

A research team from Skoltech, the Institute of Physical, Chemical, and Biological Problems of Soil Science of the Russian Academy of Sciences, and other scientific organizations in Russia and the U.S ...

The human genome — the complete set of DNA found in all humans — is around 99.9% identical in all people, but that 0.1% of variation is enough to distinguish between every human to ever live ...

By enabling multigenerational tracking of DNA damage, the authors shine a light on how cellular heterogeneity and genome instability arise, one cell division at a time. Nature 642, 576-577 (2025) ...

In addition to real-time measurements under the microscope, the researchers examined various endpoints, such as the strength of different stress signals in daughter and granddaughter cells.