The scientists found that within an hour of infection, HSV-1 co-opts two genes — RNA polymerase II (RNAP 2) and DNA topoisomerase (TOP1) — that compact the host’s chromatin into super-dense bundles.

Histone tails and their epigenetic modifications play crucial roles in gene expression regulation by altering the architecture of chromatin. However, the structural mechanisms by which histone tails ...

The ChIA-PET analysis revealed chromatin interactions, including those between the promoter and superenhancer regions, but it remained unclear to what extent superenhancers represent a sum of ...

Chromatin is a flexibly joined chain of nucleosomes that exists inside the nucleus of eukaryotic cells and has been described as a 'bead on a string'. Chromatin organization strengthens DNA for ...

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, ...

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, ...

A UNIGE team has identified two new proteins that regulate gene expression, a discovery that could pave the way for new cancer and brain disorder treatments.

In this domain, we find that the number of chromocenters is reduced, as shown by chromatin staining and labeling, and that the expression of linker histone H1.3 is induced. As further evidence of the ...

Researchers have identified several uncharacterized chromatin factors and a gene that are involved in DNA repair.

However, the extent to which lamins and nesprins regulate distal non-LAD chromatin interactions and isoform switching remain largely unexplored. 11,12. This study aims to dissect the roles of lamin A, ...

Industrial companies Chart Industries Inc. and Flowserve Corp. agreed to merge in a deal valuing the combined company at about $19 billion.. Chart shareholders will receive 3.165 shares of ...