The scientists found that within an hour of infection, HSV-1 co-opts two genes — RNA polymerase II (RNAP 2) and DNA topoisomerase (TOP1) — that compact the host’s chromatin into super-dense bundles.

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, ...

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, ...

A UNIGE team has identified two new proteins that regulate gene expression, a discovery that could pave the way for new cancer and brain disorder treatments.

Researchers have identified several uncharacterized chromatin factors and a gene that are involved in DNA repair.

His son Beau died in 2015 from glioblastoma, an aggressive form of brain cancer. When Mr. Biden was asked in January, shortly before leaving office, whether he would have had the vigor to serve ...

First, chromatin condensates are representative of the many condensates that form through multivalency-driven liquid–liquid phase separation (LLPS) (23, 25). Second, they present significant technical ...

However, as chromatin can form a huge variety of unpredictable 3D conformations, understanding how they influence genetic function has been a long-standing challenge. Previously, high-throughput ...

Lamina-associated domains (LADs) are chromatin regions at the inner nuclear membrane that form a repressive environment for transcription. Here, a haploid genetic screen revealed that chromatin ...

In principle, and in analogy to sister chromatid cohesion establishment, cohesin could form interphase chromatin loops by sequential topological capture of DNA sequences along the same chromatin chain ...

Chromatin organization plays a key role in gene regulation throughout the cell cycle. Understanding the dynamics governing the accessibility of chromatin is crucial for insight into mechanisms of gene ...