Often, marker genes are simply genes that have been found in specific cell populations. However, many more genes could be characteristic of a particular cell type but remain undiscovered.

Despite recent progress in the field, a key obstacle in maintaining the new identity of reprogrammed cells lies in their original DNA methylation patterns—crucial markers that define cell ...

Our study addresses this challenge by resolving the heterogeneity of human stem cell–derived islet organoids and introducing a functional marker to isolate transplant-ready islets," said Dr ...

Our study addresses this challenge by resolving the heterogeneity of human stem cell–derived islet organoids and introducing a functional marker to isolate transplant-ready islets." ...

Degree of cell crowding in the early human embryo influences cell identity decision, new culture system finds Date: March 4, 2024 Source: Babraham Institute ...

The team also investigated whether cellular gene expression programs that define cell identity change as the animals age. "For example, compared to the flight muscle identity marker Nig1 in young ...

TW: For the last 17 years, the intestinal stem cell field has assumed that Lgr5, a protein on the cell’s surface, is a specific marker for intestinal stem cells.

Exhausted T cells were bailing on ACSS2 and relying heavily on ACLY, forcing themselves to use more citrate and less acetate to create acetyl-CoA, despite equal availability of both nutrients.

"For example, compared to the flight muscle identity marker Nig1 in young flies, the marker in older flies is dramatically decreased, while other markers began to appear as the flies grew older ...

Through single-cell RNA-sequence analysis comparing young mice (8–10 weeks old) with aged mice (18–20 months old), the researchers identified Clusterin (Clu), a molecular chaperone, as a novel ...