For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

Unger was able to nip calcium transients in the bud by injecting a “puff” of sTREM2 into the mouse brain with a pipette; this temporarily silenced nearby neurons, and it did so in wild-type or TREM2 ...

Vaccine Step Down. A person’s probability of developing dementia over seven years increased with age. It was higher in the ...

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It binds both transmembrane and soluble TREM2, triggering a rise in CSF sTREM2. Single and multi-dose studies of the small ...