Mice that lack IRF4 cannot mount an antibody response and lack plasma cells and cytotoxic T cells 72, which suggests an important role for IRF4 in plasma cell development and/or function.

Plasma cells are a common cell to target for therapy, and physicians and scientists rely on their proper function to build antibodies once we are exposed to low concentrations of disease. For example, ...

Your plasma is composed mainly of water, and it also contains minerals, proteins, and hormones. Sometimes, when blood is ...

T-bet is a transcription factor, one of the control proteins in the cell nucleus that can turn specific groups of genes on ...

Plasma cells, crucial for long-term immunity, are programmed early to migrate to protected sites like the bone marrow. High expression of integrin β7 and the transcription factor KLF2 in these ...

Researchers show for the first time that engineered human plasma B cells can be used to treat a disease -- specifically leukemia -- in a humanized animal model. The results mark a key step in the ...