Cornell researchers have found a new and potentially more accurate way to see what proteins are doing inside living cells - using the cells' own components as built-in sensors.

Proteins are the infinitely varied chemicals that make cells work, and science has a pretty good idea how they are made. But ...

Summary: New research reveals how a tiny chemical mark on RNA helps wire the brain during development. Scientists discovered ...

Scientists have discovered the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact ...

Scientists have made a discovery that has the potential to pave the way to more efficient vaccine and mRNA drug delivery.

Details appeared recently in Nature Biomedical Engineering, in an article titled, “ Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical ...

Siloxane nanoparticles unlock precise organ targeting for mRNA therapy Changes to chemical structure allow for tissue-specific delivery Date: October 1, 2024 Source: University of Pennsylvania ...

By adjusting the chemical structure of lipid nanoparticles, the researchers were able to target different organs, presaging a new era in precision medicine. Credit: Lulu Xue and Michael J. Mitchell ...

They tested mRNA structures with zero to three branches and three different kinds of chemical modifications. The modifications were phosphorothioate (PS), DNA, and 2’-O-methoxyethyl (2MOE).

My collaborators and I are exploring other types of solids that might not need such low temperatures. We’re also looking at ways to temporarily change the mRNA chemical structure to keep it from ...

“If you look at the structure of mRNA, it’s set up to fall apart,” Topp said. “When we’re trying to use it for things like vaccines and pharmaceuticals, we have to figure out how to keep that from ...

So the researchers modified the U nucleoside to create a pseudouridine, a chemical compound which stabilises RNA’s structure. When they repeated their experiment with the modified mRNA, the mice ...