Assessing the distribution of a medication in the brain is critical for the treatment of a vast range of neurological ...

Sigvotatug Vedotin is an ADC that targets integrin αvβ6-positive tumor cells. It has an engineered antibody that ensures high ...

Every protein in the body is encased in a water shell that directs protein structure, provides vital stability and steers ...

Washington State University researchers have discovered how the bacteria that cause anaplasmosis and Lyme disease hijack ...

SARS-CoV and SARS-CoV-2 bind to the human ACE2 receptor in practically identical conformations, although several residues of the receptor-binding domain (RBD) differ between them. Herein, we have used ...

Researchers have produced multimeric, ultra-sensitive aptamers that have potential in both diagnostic and therapeutic ...

Figure 1.Heparin mediates SARS-CoV-2 Omicron BA.1 interaction with α v β 3 integrin. (A) BA.1 (blue line) and XBB.1.5 (purple line) RBDs or BA.1 (red line) and XBB.1.5 (black line) spike proteins were ...

Among the defining achievements of SG60 is Singapore’s transformation into a global health innovator. The latest chapter ...

Scientists have unearthed a rare class of ultra-potent antibodies derived from llamas that can neutralize a vast array of coronaviruses—including SARS-CoV-1 and multiple forms of SARS-CoV-2, both old ...

Powerful llama-derived antibodies could be the key to stopping not just current SARS viruses, but future ones too. Scientists ...

The team used a similar approach to model the dynamic transformations that the SARS-CoV-2 Spike protein undergoes after binding its receptor and while literally moving towards fusion. To accomplish ...

Multidisciplinary AI- and physics-driven modeling of the viral fusion process has enabled the discovery of an orally available drug inhibiting infection with multiple coronaviruses.