CeSPIACE: A broad spectrum peptide inhibitor against variable SARS-CoV-2 spikes
SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 ...
News-Medical.Net on MSN6d
Breakthrough peptide inhibitor effective against multiple SARS-CoV-2 variants
SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 (ACE2) receptors.
C&EN3d
Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?
The RBD of the spike protein is known for its high mutation rate, permitting the virus to alter its structure to evade the neutralizing ... simultaneously strengthening its binding affinity for ACE2, ...
C&EN5d
Design of Mimetic Antibodies Targeting the SARS-CoV-2 Spike Glycoprotein Based on the GB1 Domain: A Molecular Simulation and Experimental Study
One of the significant results of this study is the discovery of new structural motifs, which can be designed in an original and innovative way based on the MA structure itself ... also known as Spike ...
eLife11d
Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike
It will be of interest to scientists focusing on SARS CoV2 protein structure and dynamics ... receptor angiotensin-converting enzyme 2 (ACE2) and mediating viral-host membrane fusion. The SARS-CoV-2 ...
indrastra28d
New COVID-Like Bat Virus Discovered at China’s Wuhan Lab Raises Global Concerns
What sets HKU5-CoV-2 apart—and what has alarmed some observers—is its ability to bind to the human ACE2 receptor, the same cellular gateway ... 2 is the presence of a furin cleavage site in its spike ...