The COVID pandemic illustrated how urgently we need antiviral medications capable of treating coronavirus infections. To aid ...

A study published in mBio details the vulnerability of coronaviruses to inhibitors of a small protein domain called Mac1, or the "macrodomain," found in all coronaviruses such as SARS-CoV-2 and ...

WYS-633 also prevented SARS-CoV-1, MERS, and multiple SARS-CoV-2 variants from infecting cells ... discovery of drugs against a number of other virus families utilizing membrane fusion proteins, ...

Multidisciplinary AI- and physics-driven modeling of the viral fusion process has enabled the discovery of an orally available drug inhibiting infection with multiple coronaviruses.

Researchers assessed the impact of ceramide (CER) and cholesterol (CHOL) on membrane fusion mediated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

SARS-CoV-2 hijacks nanotubes between neurons to infect them, study finds Date: July 25, 2022 Source: Institut Pasteur Summary: Scientists have used state-of-the-art electron microscopy approaches ...

In this article, the authors discuss the challenges of SARS-CoV-2 infection in patients with a weakened immune system, including the potential implications regarding viral evolution and transmission.

The spike protein is the main part of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the infection. It consists of two subunits S1 and S2. Upon entry of the virus ...

Their simulations reveal how the SARS-CoV-2 fusion peptide interacts with, and penetrates, the cell membrane. "Our study shows which parts of the fusion peptide are important and how it sticks to ...

Their simulations reveal how the SARS-CoV-2 fusion peptide interacts with, and penetrates, the cell membrane. "Our study shows which parts of the fusion peptide are important and how it sticks to ...

The SARS-CoV-2 virus inserts itself into the membrane of a host human cell using a small part of its spike protein (yellow), called a fusion peptide. Computer simulations revealed the parts of ...