As scientists, we often think we understand a virus—its structure, its tricks, the way it moves through the body. But every ...

The COVID-19 pandemic highlighted the urgent need for effective therapeutic agents against SARS-CoV-2. Although vaccines ...

Small-molecule inhibitors targeting viral proteins could serve as an effective alternative for controlling the spread of COVID-19 at both individual and community levels. In this vein, a recent study ...

(A) A comprehensive analysis of caffeine binding to one of the spike proteins; (B, C) Caffeine interacts with critical amino acids in the SARS-CoV-2 S ... with viral entry mechanisms, thereby ...

ABSTRACT: SARS-CoV-2 poses a significant risk to global healthcare systems based on the recent worldwide COVID-19 pandemic. Spike proteins are the hallmark of SARS-Cov-2, which bind to ACE2 receptors ...

In the forthcoming paragraphs, we have discussed their primary usages and mechanism of action. In summary, we have identified 18 FDA-approved drugs which effectively inhibit the ACE2-dependant entry ...

The trimeric spike protein plays an essential role in the SARS-CoV-2 virus lifecycle, facilitating virus entry through binding to the cellular receptor angiotensin-converting enzyme 2 (ACE2) and ...

CoV-2, a new merbecovirus found in bats across China, that utilises the ACE2 receptor for cellular entry—raising concerns ...