In contrast to previous DNA-protein cross-linking studies, this approach maps the position of amino acid residues on proteins that are exposed and in proximity to specific positions of promoter DNA.

In contrast, the dinucleotides in CpG islands, especially those associated with gene promoters, are usually unmethylated, whether or not the gene is being transcribed. 2 The importance of DNA ...

When DNA’s repair machinery tries to get “under the hood,” it sometimes has trouble getting to promoter regions, which tend to have more than their share of mutations.

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 1999;59:793-797 ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

How cells ensure appropriate access to 'promoter' DNA, the regions where gene transcription begins, is still poorly understood.

Experts say there’s no evidence that the mRNA COVID-19 vaccines are ‘adulterated’ If a contaminant were found in a vaccine, the FDA would investigate and decide if it is a safety issue.

The complete structure of human TFIID and functional conformation landscape of the transcription pre-initiation complex reveal a mechanistic model of TBP loading onto promoter DNA.

The 35S promoter would have to be somehow spliced out of the plant DNA and be successfully transferred into an area of human DNA where it might drive a harmful gene.