Conan O'Brien will receive the Mark Twain Prize on Sunday night at the John F. Kennedy Center for the Performing Arts, where ...

Comedian Conan O'Brien walks out on stage at the start of the 25th Annual Mark Twain Prize for American Humor Celebrating ...

The Mark Twain Prize for American Humor has become the ultimate honor for any American in comedy. Presented by the John F. Kennedy Center for the Performing Arts in Washington, D.

Conan did such a good job, the Oscars announced that next year they’re giving it to Jay Leno to host.” That was a reference to the botched Tonight Show transition at NBC where O’Brien ...

This night is about Conan, but it can be both ... longer than any other host. O'Brien was later tapped to replace Jay Leno as host of "The Tonight Show," but that experiment ended in public ...

Video above: Conan O'Brien talks about 'sensitive' Oscars ceremonyO ... O'Brien was later tapped to replace Jay Leno as host of "The Tonight Show," but that experiment ended in public failure.

PHOTOS: Conan O'Brien accepts Mark Twain Prize for humor ... Mr. O’Brien was later tapped to replace Jay Leno as host of “The Tonight Show,” but that experiment ended in public failure.