AHA/ASA Journals15h
Lymphatic Endothelial Branched-Chain Amino Acid Catabolic Defects Undermine Cardiac Lymphatic Integrity and Drive HFpEF
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but ...
EMBO Press12h
Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures
Multi-epitope immunopurifications of huntingtin (HTT) from vulnerable brain regions of Huntington’s disease (HD) models ...
EMBO Press15h
Dimerization of GAS2 mediates crosslinking of microtubules and F-actin
GAS2 is a cytoskeletal regulator that interacts with both F-actin and microtubules. Here, cryo-EM structures of GAS2 domains ...
A starting signal for cell division: Molecular switch ensures that cells divide at the right time
About 100 cells divide every second in our body. A key protein in cell division is a protein kinase termed Plk1, because it activates other proteins involved in this process. Plk1 is also ...