Director Ricardo Gamboa tackles Chicago’s history and present of police violence in their production of the modern classic.

The stalk of the hemagglutinin protein evolves more slowly, meaning antibodies that recognize it may offer broader protection across different flu strains. Prior flu exposure and H5N1 immunity To ...

Antibodies that target the hemagglutinin stalk region, which is preserved across different influenza isolates including H5N1, circumvent this challenge.

Antigenic structures conserved across various influenza strains are ideal immunogens for universal influenza vaccines. However, viruses tend to hide their conserved functional domains, rendering these ...

First, Heaton’s team aimed to create a group of mutated hemagglutinin proteins with a wide variety of mutations only in the head region, but with conserved stalks.

Flu shots -- and immune systems -- tend to target the bulb-like “head” of hemagglutinin rather than the stalk. But the details of that head region also change constantly, creating an arms race ...

Flu shots -- and immune systems -- tend to target the bulb-like “head” of hemagglutinin rather than the stalk. But the details of that head region also change constantly, creating an arms race between ...

Duke University researchers have developed a new flu vaccine targeting the more stable stalk region of the hemagglutinin protein, showing promise in mice and ferrets for providing broader, ...

Here, we develop a broadly cross-reactive influenza vaccine by functionalizing self-assembled protein nanocages (SAPNs) with multiple copies of the hemagglutinin stalk on the outer surface and matrix ...

Similarly, vaccinees within the <50-year-old group showed a higher increase in anti-stalk antibody titers when compared to older individuals (≥80 years old), especially for group 1 anti-stalk ...

Influenza virus hemagglutinin (HA) stalk-specific antibodies have been shown to potently induce Fc-mediated effector functions which are important in protection from disease. In placebo-controlled ...

But hemagglutinin is a moving target. It consists of a stalk topped by a head that is especially prone to evolve, causing small changes to accumulate within each circulating strain.