The minus-strand HBV DNA genome is synthesized by reverse transcription of the 3.5-kb pregenomic RNA (pgRNA), after copackaging of the pgRNA and HBV polymerase inside the icosahedral nucleocapsids.

Whereas human cellular DNA contains over 20,000 genes, HBV’s DNA genome only contains four. None of the viral proteins made from these genes is required for the conversion of rcDNA to cccDNA.

Summers, J, O'Connell, A, Millman, I. Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from Dane particles. Proc Natl Acad Sci U S A 1975;72:4597-4601 Crossref ...

Chronic hepatitis B infection is primarily driven by persistence of HBV cccDNA and integration of HBV DNA into the human genome in liver cells, the primary source of HBsAg in late-stage disease.

The genome of HBV exists in two forms including the circular covalently closed DNA (cccDNA) and rcDNA. In early HBV infection, the genomic rcDNA is converted to cccDNA in the newly infected cell ...

Chronic hepatitis B infection is primarily driven by persistence of HBV cccDNA and integration of HBV DNA into the human genome in liver cells, the primary source of hepatitis B surface antigen ...

In a small trial of HIV/HBV co-infected patients, many of whom had lamivudine-resistant HBV, addition of adefovir decreased the HBV DNA level 3.2 log (vs. 4 log for tenofovir).

CRISPR/Cas9 therapy will fail for the treatment of Hepatitis B patients as hepatitis B virus DNA inserts into ... patients is that these patients have insertions of HBV DNA into their genome.

Once, this boy mummy was thought to have died of smallpox, but a new analysis of his now 450-year-old DNA reveals signs of hepatitis B, instead — the oldest known infection of the virus.

- PBGENE-HBV is the first in vivo gene editing program for chronic hepatitis B virus to move into global clinical trials - Company to host investor event highlighting clinical candidate safety ...