Scientists discovered a way to block hepatitis B infection using an anticancer drug, offering hope for new treatments.

Atomic force microscopy images show hepatitis B DNA in its natural state ... The Risca Lab studies the 3D architecture of the genome and how the packaging of DNA helps to control the transcription ...

Early in infection, HBV establishes an independent “minichromosome” consisting of the viral covalently closed circular DNA (cccDNA) genome and host histones. But as the authors noted ...

Occult HBV infection is defined by the existence of HBV DNA in serum, lymphoid cells (PBMC) and/or the liver and virus-genome replicative intermediates (i.e., covalently closed circular DNA ...

Hepatitis B virus (HBV) is the leading cause of cirrhosis, hepatocellular carcinoma, and liver-related death globally.1,2 The highest prevalence is found in low-income and middle-income countries ...

PBGENE-HBV, which comprises an ARCUS-encoding ... to cause expression/add function), elimination (removing a genome e.g. viral DNA or mutant mitochondrial DNA), and excision (removing a large ...

The presence and the positioning of nucleosomes on DNA can be important in directing cellular mechanisms to transcribe some genes. We found that to be the case for the HBV gene encoding protein X — ...

Hepatitis B is a liver infection that affects ... The Risca Lab studies the 3D architecture of the genome and how the packaging of DNA helps to control the transcription of genes.