Methotrexate is an antimetabolite that ... and competing with folic acid in cancer cells, resulting in folic acid deficiency and cell death. Normal cells are not spared; thus, significant side ...

Here’s why these vitamins and minerals are so important for maintaining your health — and what you can do about a deficiency. “When patients have a flare-up of Crohn’s, they can have ...

Folate deficiency could also rarely cause subacute combined ... However, some genetic (DARS mutation, biotinidase deficiency) or acquired (B 12 deficiency, methotrexate and nitrous oxide toxicity) ...

Homologous recombination deficiency (HRD) was evaluated through structural ... and influencing the tumor’s sensitivity to drugs targeting the folate pathway, such as methotrexate. The MTHFR gene is ...

Objective Neural tube defects (NTDs) are a preventable folate deficiency disorder; increasing folic acid intake through food ...

A new nanomedicine drug delivery system improves chemotherapy targeting for choriocarcinoma, shrinking tumors by 95% in mouse models. Researchers engineered polymersomes to enhance methotrexate (MTX) ...

A century ago, iodine deficiency affected kids across large swaths of the country. It essentially disappeared after some food makers started adding it to table salt, bread, and some other foods ...

Nat Clin Pract Rheumatol. 2007;3(1):26-34. Slow transport via folate receptor (lower affinity for methotrexate than for folic acid) Increased drug efflux via ATP-binding cassette (ABC) subfamily ...

The causes are largely unknown, but a new study points to a link involving a chromosomal microdeletion -- and also underscores the value of folic acid as a preventive ... Adding Folic Acid to ...

Non–high-dose methotrexate (Non-HDMTX)–based regimens for OGS have gained popularity in these regions due to ease of administration on daycare basis, low cost, and convenience. Therefore, finding ...

Such damage can cause malabsorption which, in turn, can lead to malnutrition, vitamin deficiency, and other health concerns. A gastroenterologist may be needed to diagnose and treat these ...