Methotrexate is an antimetabolite that ... and competing with folic acid in cancer cells, resulting in folic acid deficiency and cell death. Normal cells are not spared; thus, significant side ...

Here’s why these vitamins and minerals are so important for maintaining your health — and what you can do about a deficiency. “When patients have a flare-up of Crohn’s, they can have ...

Objective Neural tube defects (NTDs) are a preventable folate deficiency disorder; increasing folic acid intake through food ...

A new nanomedicine drug delivery system improves chemotherapy targeting for choriocarcinoma, shrinking tumors by 95% in mouse models. Researchers engineered polymersomes to enhance methotrexate (MTX) ...

The causes are largely unknown, but a new study points to a link involving a chromosomal microdeletion -- and also underscores the value of folic acid as a preventive ... Adding Folic Acid to ...

Methotrexate is a folic acid antagonist. It works by inhibiting the synthesis of purines and pyrimides and therefore interfering with DNA synthesis. Methotrexate affects rapidly dividing cells and ...

Objective CONCERTO was a randomised, double-blind, parallel-armed study of methotrexate (MTX ... open-label 40 mg adalimumab every other week, and 5 mg/week folic acid. Patients randomised to the 20 ...

1 There were remarkable baseline differences: patients developing AAA had more long-standing, severe disease and less often used concomitant medication including lower doses of methotrexate (MTX), ...