The Seattle Seahawks are not rebuilding. That has become crystal clear in the days following their roster shakeup kicked off by two big trades.

But behind the scenes, the cast of Heartbeat is caught up in dramas of their own. Fiona Dolman, who plays solicitor Jackie Lambert, has decided to leave after more than two years on the show.

Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...