Ligand–target dissociation rates (koff) strongly correlate with efficacy and safety profiles, as well as with the therapeutic effect of drugs. As a prototypical example, muscarinic receptor ...

Capsida’s wholly owned pipeline includes its first-in-class investigational treatment for STXBP1 developmental and epileptic encephalopathy (STXBP1-DEE), CAP-002; and potential best-in-class ...

Protein redesign is an enzyme engineering strategy that enhances a template enzyme’s properties by introducing mutations. Although the method is broadly employed for enzyme design, finding optimal ...

A change to a single gene in the bacterium Yersinia pestis has enabled one of the world’s most notorious pathogens to survive for centuries.

A change to a single gene in the bacterium Yersinia pestis has enabled one of the world’s most notorious pathogens to survive for centuries.

A new study published in Nature Microbiology has uncovered significant genetic and antigenic diversity among H9N2 avian influenza ... High prevalence of mutations such as HA-L226, NP-N52, ...

Between 2021 and 2023, 99.46% of H9N2 isolates carried the HA-L226 mutation linked to human receptor binding; 96.17% contained the NP-N52 mutation associated with resistance to the human MxA ...