Thus, N is suitable for use as antigen in enzyme immunoassays (EIAs) for the diagnosis of hantavirus infection. [22–24] The N antigenic sites, conserved among those of the Hantavirus genus, are ...

Four candidates (a155, a16, a18, a19) demonstrated antigen binding, with a155 and a18 showing the strongest responses. These two top candidates were then subjected to plaque reduction neutralization ...

Previous experimental studies demonstrated that membrane association drives avidity for several potent broadly HIV-neutralizing antibodies and its loss dramatically reduces neutralization. In this ...

Conclusion— HIT antigens are formed when charge neutralization by polyanion allows positively charged PF4 tetramers to undergo close approximation. Whereas such a model could explain why all 3 ...

Prediction of neutralization antibodies is important for the development of effective vaccines and antibody-based therapeutics. Traditional methods rely on features based on first principles derived ...

PDS0202 (Infectimune® + COBRA influenza antigens) vaccination also prevented illness/weight loss Vaccine protected against replication of the virus in the lungs of ferrets after challenge with ...

In addition to active neutralization of various influenza strains, the data demonstrated that PDS0202 prevented illness, weight loss and importantly protected the lungs of vaccinated animals from ...

In previous preclinical studies, PDS0202 demonstrated the ability to promote robust induction of broadly neutralizing influenza-specific antibodies, flu-specific CD4 (helper) and CD8 (killer) T cells, ...

Predicting antibody-antigen interactions is based on predicting the antigen-antibody binding sites, differentiating the binders from non-binders, and deciphering the neutralization vs. non ...

Antigens are molecules capable of stimulating an immune response. Each antigen has distinct surface features, or epitopes, resulting in specific responses. Antibodies (immunoglobins) are Y-shaped ...