Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Animals entrain their circadian rhythms to ...

Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. Here, we identify formyl-peptide receptor type 2 (FPR2) as a ...

ADHD is a prevalent neurodevelopmental disorder characterized by predominant symptoms in the domains of inattention, hyperactivity, and impulsivity, either individually or combined, and primarily ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

The ubiquitin system is an integral part of cellular responses to environmental changes. The post‐translational modification of proteins with ubiquitin modulates virtually every cellular pathway and ...

Motile cells can use and switch between different modes of migration. Here, we use traction force microscopy and fluorescent labeling of actin and myosin to quantify and correlate traction force ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

Intriguingly, single-cell transcriptome profiling of fetal gonads from both humans and mice shows that MCM8 is also highly expressed in PGCs undergoing rapid mitosis (Li et al, 2017; Niu and Spradling ...

PHOSPHATE STARVATION RESPONSE 1 (PHR1) is a master transcription factor involved in the Pi starvation in A. thaliana.Under Pi starvation conditions, PHR1 binds to the PHR1‐binding site (P1BS) element ...

Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer ...