Amlodipine is used for the treatment of hypertension, but reports on its use in early pregnancy are limited. The odds of birth defects in Group A in the first trimester were not significantly ...

Ischemic stroke in younger adults is far less common than that among older adults, yet the underlying pathogeneses and risk factors are more diverse. Approximately 10% to 15% of all strokes occur in ...

Invasive cardiopulmonary exercise testing is required to diagnose exercise-induced pulmonary arterial hypertension (PAH), exercise-induced heart failure with preserved ejection fraction (HFpEF), and ...

Cardiovascular disease (CVD) remains a major health burden despite significant therapeutic advances accomplished over the last decades. It is widely and increasingly recognized that systemic ...

Resistant hypertension is defined as failure to achieve goal blood pressure (BP) <140/90 mm Hg (or <130/80 mm Hg in patients with diabetes mellitus or chronic kidney disease) in patients with ...

The Editors of Circulation: Cardiovascular Quality and Outcomes are pleased to announce a new Patient or Caregiver Viewpoint section in the Journal. Viewpoints will be authored by patients or their ...

Letter by Forfia and Borlaug Regarding Article, “Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction: A Target of Phosphodiesterase-5 Inhibition in a 1-Year Study” ...

In this issue of Circulation: Cardiovascular Interventions, Wasfy et al 13 present information that begins to address this gap in knowledge. The authors conducted a comprehensive medical record review ...

Increased renin gene expression along with hypertrophy of JGCs is found during long-term, enhanced renin release. In addition to the hypertrophy of juxtaglomerular cells, the abovementioned ...

In this issue of Circulation, van Loosdregt et al 7 performed a comprehensive inventory of cytokines, chemokines, and chemokine receptors expressed in human arteriosclerotic versus referent ...

Background— The ability to derive human induced pluripotent stem (hiPS) cell lines by reprogramming of adult fibroblasts with a set of transcription factors offers unique opportunities for basic and ...

Along with our entire team, I have learned a great deal in the 2 years since I was tapped to be Editor-in-Chief of Circulation. Now, looking back, I have reflected on the insights we’ve gleaned during ...