At least 16 people were killed in weather-related fatalities this week, including tornadoes that destroyed entire neighborhoods.

Significant severe weather and life-threatening flash flooding continue to impact much of the mid-South up through the Ohio River Valley.

At least 16 people have been killed in a wide swath of violent storms, flooding and tornadoes that hit the South and Midwest.

As communities in the central US grapple with widespread devastation from a line of deadly storms that spawned dozens of tornadoes this week, forecasters are warning of another grave threat to the region: relentless rain into the weekend,

Another round of torrential rain and flash flooding came Saturday for parts of the South and Midwest already heavily waterlogged by days of severe storms that also spawned deadly tornadoes.

A storm system sweeping over large areas of the U.S. South and Midwest has resulted in at least 16 weather-related deaths, with overnight tornado and flash flood warnings setting up more severe weather.

Waters continued to rise in communities from Arkansas to Michigan as the storm, which has killed at least eight, drenched the region. More tornadoes were also possible.

An unabated wave of severe storms is continuing its onslaught on states like Mississippi, Tennessee, Kentucky, Arkansas, Missouri and Indiana, unleashing life-threatening flash flooding, tornadoes and widespread damage.