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Identified polymorphism in spike protein RBD mapped to the structure of spike protein in SARS-CoV-2 in complex with ACE2 in humans.
ACE2 expression was significantly reduced only in cells that expressed the viral spike protein, and the decrease in ACE2 levels was dose-dependent.
After the spike protein attaches to the ACE2 receptor, the viral and the human cell membranes fuse. This fusion creates an opening for the virus to invade human cells and start infecting a person ...
The novel coronavirus uses its "spike proteins" to latch onto and invade human cells. But to do so, the spikes morph into at least 10 different shapes, according to a new study.
The spike protein of SARS-CoV-2 can adopt at least ten distinct structural states when in contact with the human ACE2 cell surface receptor.
Studies of coronaviruses indicate that spike-ACE2 recognition is the basis for infection. The researchers focused on screening the mutations located where the spike protein and ACE2 receptor meet.
An accessible guide to how SARS-CoV-2 uses its spike protein to invade a human cell, and the specific molecules that scientists could target to prevent the viral infection leading to COVID-19.
ACE2 is a protein that researchers think could be the gateway for SARS-CoV-2 to enter the cells. Here's what we know about this protein and its role in the body.
The spike protein eventually binds to ACE2 at all three of its binding sites, revealing it's "central core," according to a statement. This final structure likely allows the virus to fuse to cell ...