As scientists, we often think we understand a virus—its structure, its tricks, the way it moves through the body. But every ...

The method first takes a given SARS-CoV-2 spike protein sequence and simulates ... a measure that has been used to study protein structure and function, but never before applied to mutation ...

It's been five years since COVID-19 was declared a global pandemic. As SARS-CoV-2 shifts to endemic status, questions about ...

The COVID-19 pandemic highlighted the urgent need for effective therapeutic agents against SARS-CoV-2. Although vaccines ...

The spike protein of the coronavirus, or SARS-CoV-2, binds to ACE2, a receptor on the host cells ... “We simulated the electronic structure of the two interacting molecules and assessed how amino ...

For the study, they focused on the SARS-CoV-2 spike protein – the part of ... for mutations that cause only small changes in the protein's structure and function. This is important because ...

Specifically, we developed a statistical mechanics model that connects the thermodynamic properties of the virus's spike protein to its ability to spread. The key player in SARS-CoV-2's infection ...

Small-molecule inhibitors targeting viral proteins could serve as an effective alternative for controlling the spread of COVID-19 at both individual and community levels. In this vein, a recent study ...

Viruses like SARS-CoV-2 use sugar molecules to hide from the immune system, but scientists at Scripps Research have designed ...

such as those for the spike protein, inserting the blueprints into DNA, RNA or a safe virus and injecting those into people. The Remarkable and Mysterious Coronavirus Genome The SARS-CoV-2 genome ...

A SARS-CoV-2 antibody, NT-108, exhibits potent therapeutic effects in vivo. Cryo-EM structure of the spike complexed with single-chain Fv of NT108 reveals its neutralizing mechanism, providing ...

SARS-CoV-2, the virus responsible for COVID-19 ... However, mutations in the spike protein can alter its structure, reducing the effectiveness of these inhibitors. In a significant breakthrough, a ...