SARS-CoV-2 viral particles into human cells, mediated by ACE2. (b) Cellular infection by ACE2- spike mediated cell-cell fusion. Infection in human (h) cells is used as an example.

New research indicates that SARS-CoV-2 may be able to impact viral pathogenesis without entering host cells— extracellular binding of the spike protein to host ACE2 has the potential to alter ...

Prefusion Spike Protein Conformational Changes Are Slower in SARS-CoV-2 than in SARS-CoV-1. Journal of Biological Chemistry , 2022; 101814 DOI: 10.1016/j.jbc.2022.101814 Cite This Page : ...

Dec. 8, 2020 — The binding of a SARS-CoV-2 virus surface protein spike -- a projection from the spherical virus particle -- to the human cell surface protein ACE2 is the first step to infection ...

Spike protein accumulates in the brain. A novel AI-powered imaging technique developed by Prof. Ertürk's team provides new insights into how the SARS-CoV-2 spike protein affects the brain.

In humans, lingering spike protein was seen in 10 of 34 skull samples of people who had recovered from SARS-CoV-2 infection and died of non-COVID-related causes in 2021 and 2022.

The spike protein of SARS-CoV-2, the virus that causes COVID-19, has been the focus of a lot of research these past two years. It’s what the virus uses to invade host cells and it has been the ...

Allowing SARS-CoV-2 entry into the host cell, the spike protein plays a key role in the infectivity of the virus and protein mutations can have a large impact. Skip to content Menu ...

New computational simulations of the behavior of SARS-CoV-1 and SARS-CoV-2 spike proteins prior to fusion with human cell receptors show that SARS-CoV-2, the virus that causes COVID-19, is more ...

The researchers’ study, “Prefusion Spike Protein Conformational Changes Are Slower in SARS-CoV-2 than SARS-Cov-1,” was published in Journal of Biological Chemistry. Journal Method of Research ...