Glyburide, metformin HCl; 2.5mg/500mg, 5mg/500mg; tabs. Take with meals. Individualize. Not controlled on diet/exercise (use individual components): initially glyburide 1.25mg and metformin 250mg ...

Data Synthesis: Studies of glyburide and glipizide have found little or no transfer of these drugs across the placenta, whereas metformin and rosiglitazone cross readily. Animal studies have found ...

Over the past two decades, oral glucose-lowering agents like metformin and glyburide have gained attention as easier-to-administer, cost-effective alternatives with better patient acceptance.