Methotrexate, a common treatment for rheumatoid arthritis, can cause folate deficiency. Natural folate can be consumed from leafy vegetables. A doctor may prescribe folic acid supplementation to ...

Folic acid deficiency anemia leads to fatigue, weakness, and irritability. ... Drugs such as methotrexate, phenytoin, sulfasalazine, and barbiturates can block folate absorption.- ...

Folic acid is the synthetic form of folate, ... Doctors may use folic acid to support a methotrexate prescription for rheumatoid arthritis. ... Folic acid deficiency. https: ...

Study: Folic acid and methotrexate use and their association with COVID-19 diagnosis and mortality: a case–control analysis from the UK Biobank.Image Credit: Pixel-Shot / Shutterstock ...

It’s thought that folic acid can potentially affect how well methotrexate works for cancer. Folic acid supplement side effects Folic acid doses up to 400 mcg per day are generally considered safe.

Folic acid deficiency can also occur in pregnancy, as people require higher levels of folic acid during pregnancy and breastfeeding. Alcohol use disorder (AUD) is also a significant cause of folic ...

More information: Ruth Topless et al, Folic acid and methotrexate use and their association with COVID-19 diagnosis and mortality: a case–control analysis from the UK Biobank, BMJ Open (2022 ...

In a prospective study published in , researchers evaluated the effectiveness of methotrexate -- including adverse events and the impact of folic acid on GI events -- on 105 pediatric patients ...