Our immune system is constantly working to protect us from infections and injuries. One of its most powerful tools is ...

Deficient or excessive activation of the complement system may lead to severe disorders, including micro-thrombotic, autoimmune, and neurological diseases that can have severe or even fatal ...

Harvard Medical School scientists have identified a key protein in the human immune system that drives inflammatory and ...

how the system is controlled and how pathogenic microbes, parasites and tumor cells escape complement attack. Abnormalities in complement regulation lead directly to a variety of immunological ...

But sometimes the system is overactive leading to damage of also our own cells and tissues (in autoimmune diseases) or does not protect us well enough leading to serious infections. The aim of our ...

Our immune system is armed with an array of ... GZMK as a promising therapeutic target to inhibit complement activation across multiple diseases. Unlike traditional therapies that broadly inhibit ...

Alexion has announced a collaboration with Dicerna Pharmaceuticals to discover and develop RNA interference therapies for diseases caused by problems in the complement system. Boston-based Alexion ...