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Syncytia formation followed by the vacuolization of infected cells may account for the widespread lung damage seen in severely ill COVID-19 patients.
The viral growth rate was measured using plaque test titration on HT1080 cells of cell culture supernatant from HT29 cells. HT29 cells were infected at MOI 0.01, MOI 0.001 and MOI 0.0001.
Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology. EBioMedicine , 2020; 103104 DOI: 10.1016/j.ebiom.2020.103104 Cite This Page : ...
Cell culture is integral to the future of drug discovery, but it suffers from a lack of reproducibility owing to inconsistent quality control. 3D cell models are showing ever increasing promise in ...
To make further progress, researchers are now exploring cell culture alternatives that are more representative of how tissues and organs work. One such alternative is 3D cell cultures, which have the ...
Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver. Science , 2023; 381 (6662) DOI: 10.1126/science.abq5202 Cite This Page : ...