The Indianapolis Colts have everything to play for, and the New York Giants have every reason to lose. Here are the NFL Week 17 picks and predicitons.

Heading into Week 16, the Colts are on the outside of the AFC playoff field. Indianapolis sits in the No. 8 seed spot in the standings, but 2.5 games back of the Chargers and Broncos, who have nine wins.

Our experts' predictions are in for Tennessee Titans vs. Indianapolis Colts on Sunday. Here's who our experts are picking to win the Week 16 NFL game.

Welcome to Christmas Week in the NFL, otherwise known as Week 17. We have football games on five days this week in 10 different time slots, including an all-AFC Christmas Day doubleheader. We're looking to improve on our total of 87 points from last week.

Johnson: "Here’s what you need to know entering this Week 17 matchup, the New York Giants have allowed 151.3 rushing yards per game, 4.9 yards per carry and 15 rushing touchdowns in the last 11 games. The Indianapolis Colts ran the football to their last win over the Tennessee Titans, same formula here."

NFL Week 17 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Indianapolis Colts and New York Giants.

The Indianapolis Colts visit the New York Giants in NFL Week 17 action. Both teams will be watching injuries to key players.

Full NFL predictions for every Week 17 game with picks straight-up and ATS, including the huge Packers-Vikings showdown on Sunday but not before we get Chiefs-Steelers and much more on Christmas and throughout the week.