With the opening line of Duke’s Sweet 16 hovering near double digits, the Blue Devils are heavily favored in their matchup against No. 4 Arizona. Displaying dominant two-way play through two games, it’s easy to see why Duke currently sits at No. 1 entering the second weekend.

Madness picks, predictions, odds for Gonzaga vs Houston second-round Midwest Region game on Saturday, March 22, 2025. Who wins?