The expression of many eukaryotic genes is regulated at the level of translation initiation. The first step in the initiation process is binding of the small ribosomal subunit (40S) to the mRNA.

His interest in large macromolecular assemblies led him for his postdoctoral work to the Department of Molecular Biophysics and Biochemistry at Yale University where he determined the atomic structure ...

and ribosomal RNAs (rRNAs) and degradation of many non-coding RNAs including those that arise from bidirectional transcription or transcription from enhancers. The eukaryotic nuclear RNA exosome ...

First, three initiation factor proteins (known as IF1, IF2, and IF3) bind to the small subunit of the ribosome ... a sample of 170 prokaryotic and 120 eukaryotic proteins (Flinta et al., ...

The rRNA structures also provide binding sites for ribosomal proteins, which help stabilize the overall structure of the ribosome. One of the most remarkable features of rRNA is its catalytic activity ...