Bukhara Region is a region of Uzbekistan located in the southwest of the country. The Kyzyl Kum desert takes up a large portion of its territory. It borders Turkmenistan, Navoiy Region, Qashqadaryo Region, a small part of the Xorazm Region, and the Karakalpakstan Republic. It covers an area of 40,216 km. The population is estimated at 1,976,823, with 63% liviā¦Bukhara Region is a region of Uzbekistan located in the southwest of the country. The Kyzyl Kum desert takes up a large portion of its territory. It borders Turkmenistan, Navoiy Region, Qashqadaryo Region, a small part of the Xorazm Region, and the Karakalpakstan Republic. It covers an area of 40,216 km. The population is estimated at 1,976,823, with 63% living in rural areas.